Young-Adult Polycystic Kidney Disease is Associated with Major Cardiovascular Complications.

Ya-Wen Chuang, Tung-Min Yu, Shih-Ting Huang, Kuo-Ting Sun, Ying-Chih Lo, Pin-Kuei Fu, Bor-Jen Lee, Cheng-Hsu Chen, Cheng-Li Lin, Chia-Hung Kao

REVIEW


04 September 2018

Really useful study and encourages clinicians to be more aware of the increased risk of CVD in PKD


RELEVANCE 4
INNOVATIVENESS 3
APPLICABILITY 3
OVERALL 3

PAPER DETAILS


TITLE

Young-Adult Polycystic Kidney Disease is Associated with Major Cardiovascular Complications.

ABSTRACT

Patients with polycystic kidney disease (PKD) might have a risk of cardiovascular diseases because several cardiovascular risk factors are occasionally associated with PKD patients. Data on the association between PKD and the risk of cardiovascular events, including acute coronary syndrome (ACS), stroke, and congestive heart failure (CHF), are scant. Patients aged ≥20 years who were newly diagnosed with PKD (International Classification of Diseases, Ninth Revision, Clinical Modification codes 753.12 and 753.13) between 2000 and 2011 were selected as a PKD cohort (N = 5157). The association between PKD and cardiovascular events was analyzed. We randomly selected a comparison cohort of people without PKD, who were frequency-matched by sex, age, and index date of diagnosis. At the end of 2011, the PKD cohort had a 1.40-fold greater incidence of ACS compared with the comparison cohort (8.59 vs. 6.17 per 1000 person-years), in addition to a 1.40-fold greater incidence of stroke, a 1.49-fold greater incidence of CHF, and a 1.64-fold greater incidence of mortality. This retrospective cohort study shows that patients with PKD have an increased risk of cardiovascular events including ACS, stroke, and CHF as well as mortality, particularly in younger patients. Early identification is necessary to attenuate the risk of cardiovascular complications in patients with PKD.



AUTHOR(S)

Ya-Wen Chuang, Tung-Min Yu, Shih-Ting Huang, Kuo-Ting Sun, Ying-Chih Lo, Pin-Kuei Fu, Bor-Jen Lee, Cheng-Hsu Chen, Cheng-Li Lin, Chia-Hung Kao,

JOURNAL

International journal of environmental research and public health

PLACE

Switzerland