Lipid profile and incidence of atrial fibrillation: A prospective cohort study in China.

Li, Xintao Gao, Lianjun Wang, Zhao Guan, Bo Guan, Xumin Wang, Binhao Han, Xu Xiao, Xianjie Waleed, Khalid Bin Chandran, Clarance Wu, Shouling Xia, Yunlong

REVIEW


09 May 2018

Routine data collection in clinical practice means that cholesterol can provide important prognostic information for CVD. However, the finding that high TC and LDC-C are associated with a lower risk of AF has limited potential to change clinical practice because cholesterol is such an important predictor of CVD.


RELEVANCE 3
INNOVATIVENESS 2
APPLICABILITY 3
OVERALL 3

PAPER DETAILS


TITLE

Lipid profile and incidence of atrial fibrillation: A prospective cohort study in China.

ABSTRACT

BACKGROUND
The association between dyslipidemia, a major risk factor for cardiovascular diseases, and atrial fibrillation (AF) is not clear because of limited evidence.

HYPOTHESIS
Dyslipidemia may be associated with increased risk of AF in a Chinese population.

METHODS
A total of 88 785 participants free from AF at baseline (2006-2007) were identified from the Kailuan Study. Fasting levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG) were measured at baseline using standard procedures. The study population was stratified based on quartiles of lipid profile. Incident AF was ascertained from electrocardiograms at biennial follow-up visits (2008-2015). The associations between incident AF and the different lipid parameters (TC, LDL-C, HDL-C, and TG) were assessed by Cox proportional hazards regression analysis.

RESULTS
Over a mean follow-up period of 7.12 years, 328 subjects developed AF. Higher TC (hazard ratio [HR]: 0.60, 95% confidence interval [CI]: 0.43-0.84) and LDL-C (HR: 0.60, 95% CI: 0.43-0.83) levels were inversely associated with incident AF after multivariable adjustment. HDL-C and TG levels showed no association with newly developed AF. The results remained consistent after exclusion of individuals with myocardial infarction or cerebral infarction, or those on lipid-lowering therapy. Both TC/HDL-C and LDL-C/HDL-C ratios were inversely associated with risk of AF (per unit increment, HR: 0.88, 95% CI: 0.79-0.98 and HR: 0.77, 95% CI: 0.66-0.91, respectively).

CONCLUSIONS
TC and LDL-C levels were inversely associated with incident AF, whereas no significant association of AF with HDL-C or TG levels was observed.



AUTHOR(S)

Li, Xintao Gao, Lianjun Wang, Zhao Guan, Bo Guan, Xumin Wang, Binhao Han, Xu Xiao, Xianjie Waleed, Khalid Bin Chandran, Clarance Wu, Shouling Xia, Yunlong

JOURNAL

Clinical cardiology

PLACE

United States